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BN41873R-50ul
50ul
￥1486.00
交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Pig) 推薦應(yīng)用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41873R-100ul
100ul
￥2360.00
交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Pig) 推薦應(yīng)用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41873R-200ul
200ul
￥3490.00
交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Pig) 推薦應(yīng)用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA
產(chǎn)品描述
| 英文名稱 | TSPO/PBR |
| 中文名稱 | 外周苯二氮受體抗體 |
| 別 名 | BPBS; BZRP; DBI; IBP; Isoquinoline carboxamide-binding protein; MBR; mDRC; Mitochondrial benzodiazepine receptor; PBR; PBS; Peripheral benzodiazepine receptor; Peripheral benzodiazepine receptor-related protein; Peripheral type benzodiazepine receptor; pk18; PKBS; PTBR; Ptbzr; PTBZR02; RATPTBZR02; translocator protein (18kDa); Translocator protein; TSPO; Tspo1; Benzodiazapine receptor (peripheral); Benzodiazepine peripheral binding site. |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子 糖尿病 線粒體 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, Rat, (predicted: Human, Dog, Pig, ) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 18kDa |
| 細(xì)胞定位 | 細(xì)胞漿 線粒體 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PBR:31-130/169 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | PBR (Peripheral type Benzodiazepine Receptor) is a ubiquitous protein (18 kDa) found in most steroidogenic tissues. It is located primarily in the outer mitochondrial membrane of steroid producing tissues and is found in association with a 34 kDa voltage dependent anion channel protein (VDAC). PBR interacts with some benzodiazepines and has different affinities than its endogenous counterpart. PBR appears to be a key factor in the transport of cholesterol from the outer to the inner mitochondrial membrane to permit the initiation of steroid hormone synthesis. It is thought to be part of the mitochondrial permeability transition pore (PT) and to be involved in apoptosis. It is speculated that patients with congenital lipoid adrenal hyperplasia, who cannot make any steroids, might have a genetic lesion in BZRP. A short form, PBRS is also expressed in the same tissues, but at a level about ten times that of PBR. Function: Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells. Subcellular Location: Mitochondrion membrane. Tissue Specificity: Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids. Similarity: Belongs to the TspO/BZRP family. SWISS: B1AH88 Gene ID: 706 Database links: Entrez Gene: 706 Human Entrez Gene: 12257 Mouse Omim: 109610 Human SwissProt: B1AH88 Human SwissProt: P30536 Human SwissProt: P50637 Mouse Unigene: 202 Human Unigene: 1508 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 地西泮結(jié)合抑制因子； DBI能拮抗安定物質(zhì)：diazepam與腦突觸膜相結(jié)合 ,故稱之為安定結(jié)合抑制蛋白(DBI)，地西泮結(jié)合抑制因子(diazepam binding inhibitor,DBI)具有抑制由葡萄糖誘導(dǎo)的胰島素分泌、促進(jìn)膽固醇跨線粒體膜轉(zhuǎn)運(yùn)和調(diào)節(jié)脂肪酸合成與代謝等多種生理功能。 |
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