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BN41660R-50ul
50ul
￥1486.00
交叉反應(yīng)：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41660R-100ul
100ul
￥2360.00
交叉反應(yīng)：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41660R-200ul
200ul
￥3490.00
交叉反應(yīng)：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
產(chǎn)品描述
| 英文名稱 | SPARC |
| 中文名稱 | 富含半胱氨酸的酸性分泌蛋白抗體 |
| 別 名 | AA517111; Basement membrane protein 40; BM 40; BM40; Cysteine rich protein; hm:zeh0062; MGC128090; ON; Osteonectin; Secreted acidic cystein rich glycoprotein; Secreted protein acidic and rich in cysteine; Secreted protein acidic cysteine rich (osteonectin); Secreted protein acidic cysteine rich; SPRC; SPRC_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 干細(xì)胞 細(xì)胞周期蛋白 細(xì)胞骨架 細(xì)胞外基質(zhì) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, Rat, (predicted: Dog, Pig, Cow, Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 33kDa |
| 細(xì)胞定位 | 細(xì)胞膜 細(xì)胞外基質(zhì) 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SPARC:101-200/303 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. [provided by RefSeq, Dec 2011]. Function: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. Subcellular Location: Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the basement membrane. Similarity: Belongs to the SPARC family. Contains 1 EF-hand domain. Contains 1 follistatin-like domain. Contains 1 Kazal-like domain. SWISS: P09486 Gene ID: 6678 Database links: Entrez Gene: 6678 Human Omim: 182120 Human SwissProt: P09486 Human Unigene: 111779 Human Unigene: 708558 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. SPARC是從多方面調(diào)節(jié)細(xì)胞功能的細(xì)胞外基質(zhì)蛋白，SPARC蛋白在人組織中廣泛分布與組織重建和腫瘤有關(guān)。SPARC在多種腫瘤中呈高表達(dá). |
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